Hypoxia Molecular Characterization in Hepatocellular Carcinoma Identifies One Risk Signature and Two Nomograms for Clinical Management

Molecular signature of early hepatocellular carcinoma.

The advances in imaging techniques and establishment of screening and surveillance protocols for high-risk populations for hepatocellular carcinoma (HCC) have led to the detection of small hepatic nodules in patients with chronic liver diseases, but in general the prognosis for HCC remains poor. Early detection of HCC or detection of small/early HCC followed by appropriate treatment is the key ...

Molecular Signature of Early Hepatocellular Carcinoma

The advances in imaging techniques and establishment of screening and surveillance protocols for high-risk populations for hepatocellular carcinoma (HCC) have led to the detection of small hepatic nodules in patients with chronic liver diseases, but in general the prognosis for HCC remains poor. Early detection of HCC or detection of small/early HCC followed by appropriate treatment is the key ...

Prognostic molecular markers in hepatocellular carcinoma (Review article

Hepatocellular carcinoma (HCC) is the 5th commonest malignancy worldwide and is the third most common cause of cancer-related death. The prevalence is different in the world. The ability to predict patients at higher risk of recurrence and with a poor prognosis would help to guide surgical and chemotherapeutic treatment according to individual risk. As understanding of hepatocarcinogenesi...

Hepatocellular Carcinoma in Sheep

Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) ranks fifth in frequency worldwide amongst all human cancers causing one million deaths annually. Despite many promising treatment options, long-term prognosis remains dismal for the majority of patients who develop recurrence or present with advanced disease. Notch signaling is an evolutionarily conserved pathway crucial for the development and homeostasis of man...